Health Information Exchange & Interoperability

>> See our methodology here
2025 CLINICAL DATA INTEGRATION SOLUTIONS

1. Infor (Cloverleaf)
2. Lyniate Rhapsody
3. Inovalon
4. NextGen Mirth Connect (NextGen Connect)
5. Redox
6. InterSystems (HealthShare / IRIS)
7. Orion Health
8. Health Catalyst
9. Interfaceware Iguana
10. Qvera
11. Ellkay
12. Oracle Health (Cerner Ignite APIs)
13. Informatica
14. dbMotion
15. Summit Exchange
16. Epic Bridges
17. Microsoft Azure API for FHIR
18. eZintegrations™
19. Goldfinch AI
20. SAP Health Data Services

2025 HEALTH INFORMATION EXCHANGE (HIE) SOLUTIONS

1. Epic Systems (Care Everywhere)
2. Oracle Health Ignite APIs
3. InterSystems (HealthShare)
4. NextGen (Mirth Connect)
5. Meditech
6. Orion Health
7. eClinicalWorks
8. Surescripts
9. Health Catalyst
10. Optum
11. Redox
12. Audacious Inquiry
13. NextGate
14. Verato
15. CMS-Aligned TEFCA HIE Networks
16. HIE of One
17. Carequality
18. Health Gorilla
19. KONZA National Network
20. CRISP Shared Services

2025 EHR INTEGRATION TOOLS

1. Orion Health
2. Redox
3. Infor Cloverleaf
4. Rhapsody
5. InterSystems
6. Epic Systems
7. Qvera
8. Mirth Connect (NextGen)
9. Health Gorilla
10. Datica
11. Particle Health
12. Bridge Connector
13. Well Health
14. HealthJump
15. MedFusion
16. Validic
17. Zynx Health
18. eZintegrations™
19. Goldfinch AI
20. Moxe Health

ENTERPRISE MASTER PATIENT INDEX (EMPI) INTEGRATION

1. Verato
2. Rhapsody EMPI
3. InterSystems (HealthShare Patient Index)
4. NextGate
5. Reltio (Cloud EMPI)
6. Amazon Health EMPI
7. IBM Initiate EMPI
8. Oracle Health (Cerner EMPI)
9. Experian Health
10. Altera EMPI Solutions
11. Optum EMPI Services
12. QuadraMed
13. 3M Health Information Systems (EMPI Tools)
14. Change Healthcare EMPI
15. Informatica (Master Data Management)
16. HealthShare
17. ZeOmega
18. eClinicalWorks EMPI
19. CareAlign (for small providers)
20. Nuance Communications

CLOUD-BASED INTEROPERABILITY PLATFORMS

1. AWS HealthLake
2. Salesforce Health Cloud
3. Microsoft Azure Healthcare API
4. Redox Cloudv
5. InterSystems IRIS for Health (Cloud)v
6. Oracle Cloud Health
7. Google Cloud Healthcare APIv
8. Mulesoft
9. Snowflake Healthcare Data Cloud
10. Health Catalyst Cloud
11. NextGen Cloud
12. Cohesity Health Solutions
13. ClearDATA
14. IBM Cloud for Healthcare
15. Philips HealthSuite Platform
16. athenahealth Cloud
17. Innovaccer Health Cloud
18. Veeva Systems
19. Ellkay Cloud
20. Cloudera Data Platform

TELEHEALTH AND REMOTE MONITORING INTEGRATION

1. Teladoc Health
2. Amwell (incl. Avizia)
3. Philips Healthcare
4. Vivify Health
5. ResMed
6. MDLIVE
7. CareClix
8. DrChrono
9. VSee
10. Lumeon
11. Health Recovery Solutions (HRS)
12. TytoCare
13. Medtronic Care Management Services
14. Biotelemetry (Philips)
15. iHealth Labs
16. AliveCor
17. GE Healthcare Remote Monitoring
18. Validic
19. American Well
20. Huma

TEFCA / QHIN CONNECTIVITY HUBS & ENABLERS

1. CommonWell Health Alliance
2. eClinicalWorks
3. eHealth Exchange
4. Epic Systems (TIS)
5. Health Gorilla
6. Kno2
7. KONZA National Network
8. MedAllies
9. Netsmart
10. Surescripts
11. Oracle Health (Candidate QHIN)
12. Carequality
13. 1upHealth
14. Redox
15. Particle Health
16. Moxe Health
17. Velatura (MiHIN)
18. CRISP Shared Services
19. Contexture
20. Manifest MedEx

FHIR SERVERS & DATA PLATFORMS

1. Smile Digital Health
2. Microsoft Azure Health Data Services
3. AWS HealthLake
4. Firely (Firely Server)
5. Health Samurai (Aidbox)
6. InterSystems (FHIR Server / IRIS)
7. Infor Cloverleaf FHIR
8. 1upHealth (FHIR Platform)
9. SAP Health Data Services for FHIR
10. Google Cloud Healthcare API
11. Medplum
12. Kodjin (FHIR Server)
13. Oystehr
14. Blacktusk
15. HAPI FHIR (Open Source)
16. Microsoft OSS FHIR Server
17. Blaze (Samply)
18. Incendi (Firely Spark OSS)
19. CareEvolution
20. Enovacom

PAYER INTEROP & FHIR PRIOR AUTHORIZATION PLATFORMS

1. Cohere Health
2. Edifecs
3. Availity
4. 1upHealth
5. Myndshft
6. Surescripts (ePA)
7. CoverMyMeds
8. Optum / Change Healthcare
9. ZeOmega
10. MCG Health
11. HealthTrio
12. Redox
13. Moxe Health
14. Epic (Payer Platform)
15. Oracle Health (FHIR APIs)
16. Innovaccer
17. Arcadia
18. Smile Digital Health
19. Firely (Tooling / Profiling)
20. Tegria

FHIR TESTING, PROFILING & CONFORMANCE TOOLS

1. AEGIS Touchstone
2. FHIR Shorthand (SUSHI)
3. Firely Forge
4. Firely Simplifier.net
5. ONC Inferno
6. HL7 IG Publisher
7. HAPI FHIR Validators
8. MITRE Crucible
9. FSH Online
10. GoFSH
11. Inferno UDS+ Kit
12. Inferno Da Vinci CRD Kit
13. AEGIS Touchstone Education Suite
14. FHIR Validator CLI
15. SMART App Launch Test Harness
16. Bulk Data Test Suites
17. CARIN Blue Button Test Kits
18. CDS Hooks Test Packs
19. Postman Official FHIR Collections
20. US Core v7/8 Test Suites

>> See our methodology here
HEALTHCARE INTEGRATION ENGINES (TRADITIONAL MIDDLEWARE)

1. Infor Cloverleaf
2. Lyniate Rhapsody
3. NextGen Mirth Connect
4. InterSystems Ensemble / IRIS
5. Orion Health Rhapsody
6. HealthShare InterSystems Engine
7. Qvera Interface Engine (QIE)
8. Ellkay Integration Suite
9. Interfaceware Iguana
10. Corepoint (Lyniate)
11. Epic Bridges
12. Cerner OpenLink
13. Redox Engine
14. Health Gorilla Exchange Engine
15. Datica Integration Middleware
16. Moxe Health Middleware
17. Particle Health Connectivity Layer
18. Bridge Connector (Zus)
19. NextGate Integration Modules
20. Summit Healthcare Integration

API GATEWAY & CONNECTIVITY MIDDLEWARE

1. Kong Gateway
2. MuleSoft (Salesforce)
3. Apigee (Google Cloud)
4. Tyk API Gateway
5. Amazon API Gateway (AWS)
6. Microsoft API Management (Azure)
7. WSO2 API Manager
8. IBM API Connect
9. Axway API Gateway
10. Broadcom Layer7
11. Boomi (API Management)
12. SnapLogic API Gateway
13. TIBCO Mashery
14. Red Hat 3scale API Management
15. Gravitee.io
16. NGINX API Gateway (F5)
17. Sensedia Healthcare API Hub
18. Zuora Health API Services
19. Akana API Platform
20. Cloudentity

HEALTHCARE-SPECIFIC MIDDLEWARE PLATFORMS (NEXT-GEN)

1. 1upHealth
2. Health Gorilla (TEFCA Connectivity
3. Redox (Cloud Middleware)
4. Particle Health
5. Innovaccer (Data Activation)
6. Smile Digital Health (FHIR Middleware)
7. Aidbox (Health Samurai)
8. Firely (FHIR Middleware Toolkit)
9. Moxe Health
10. Zus Health
11. CareEvolution
12. Enovacom (Orange)
13. Datica (Interop + Security)
14. Validic (RPM Middleware)
15. HealthTrio (Payer-Provider)
16. ZeOmega Interop Middleware
17. Cohere Health (Prior Auth Middleware)
18. Edifecs (X12 + FHIR Middleware)
19. Availity (Gateway Middleware)
20. Medblocks (FHIR ↔ openEHR Middleware)

>> See our methodology here
NATIONAL / REGIONAL HEALTH MIDDLEWARE & INTEGRATION ENGINES
THESE ARE COUNTRY-SPECIFIC “NATIONAL SPINE” OR REGIONAL EXCHANGE ENABLERS.

1. Enovacom (France, part of Orange) – middleware for French hospitals, cross-border EHDS pilots.
2. Orion Health (New Zealand HQ, global deployments in UK, Canada, Middle East).
3. CSAM Health (Nordics) – integration engines for Norway, Sweden, Finland.
4. Tietoevry Lifecare Integration (Nordics, Baltics).
5. Dedalus X-Interop (Italy HQ, pan-Europe).
6. Rhapsody/Lyniate (widely deployed in EU health regions).
7. Cambio COSMIC Integration (Sweden).
8. InterSystems IRIS for Health (used in NHS and Middle East national systems).
9. Marand Think!EHR (openEHR middleware) (Slovenia, UK, Nordics).
10. Vitagroup HIP (EHRbase) (Germany, EU research consortia).
11. Agfa HealthCare (Orbis Connect) (Germany, France).
12. CSU (Connecting Care UK) – middleware hubs for NHS ICSs.
13. Kanta Services Middleware (Finland’s national EHR spine).
14. HIQA Exchange Platforms (Ireland).
15. Medasys Integration Engine (France, Dedalus group).
16. Helseplattformen Middleware (Norway).
17. NEC Healthcare Middleware (Japan).
18. Fujitsu Interop Solutions (Japan, NHS UK projects).
19. NTT Data Health Integration (Japan, Italy).
20. CGM (CompuGroup Medical) middleware products (Germany).

API-FIRST MIDDLEWARE FOR EU & APAC
FOCUSED ON EHDS COMPLIANCE, GDPR-ANCHORED CONSENT, FHIR/OPENEHR BRIDGES.

1. Better Platform (Slovenia/UK) – openEHR-native middleware.
2. Medblocks (India) – FHIR ↔ openEHR middleware for APAC/Africa.
3. Ripple Foundation (UK) – QEWD.js middleware for openEHR + FHIR.
4. Ehiway (Spain) – regional interoperability middleware.
5. HiGHmed (Germany) – research network middleware with openEHR.
6. Vitagroup (Germany) – HIP openEHR ↔ FHIR.
7. Dedalus AMEA Interop (Middle East, Asia).
8. Surescripts Int’l Partners (middleware for Rx/medication data in Canada).
9. Telstra Health Integration Hub (Australia).
10. HealthLink International (New Zealand/Australia).
11. NHS Digital Middleware Services (UK Spine 2 API platform).
12. Lyniate Rhapsody EU Editions (localized GDPR-ready versions).
13. Horizon Middleware (Singapore).
14. eHealth NSW Middleware (Australia).
15. Medsphere OpenVista Integration (Asia, LATAM).
16. Cerner Middle East Connect Middleware.
17. Allscripts/Altera Paragon Denali Integration (Middle East hospitals).
18. SystmOne/TPP Interop Services (UK).
19. Orion Health Amadeus Cloud Middleware (UK, EU, Middle East).
20. Visiba Care APIs (Sweden).

NON-U.S. REMOTE MONITORING & IOT MIDDLEWARE
WHERE IOT DEVICES AND REMOTE CARE DATA MUST LAND INTO NATIONAL RECORDS.

1. Philips HealthSuite (Europe HQ, Netherlands).
2. Siemens Healthineers Digital Middleware (Germany).
3. Bosch Healthcare IoT Hub (Germany).
4. Withings Health APIs (France).
5. Telekom Healthcare Solutions (Germany).
6. Nihon Kohden Middleware (Japan).
7. Hitachi Health Middleware (Japan).
8. SoftBank Health IoT Middleware (Japan).
9. Ping An Good Doctor APIs (China).
10. Alibaba Cloud Healthcare Middleware (China).
11. Tencent Healthcare Integration (China).
12. M3 Health APIs (Japan).
13. Fujitsu Health IoT (Japan, UK).
14. Tunstall Healthcare Middleware (UK/EU).
15. B. Braun Health Middleware (Germany).
16. GE Healthcare Edison (global).
17. Cerner i.s.h.med Connect (Siemens partnership, Germany).
18. Dedalus Care4U Integration (Italy/EU).
19. NHS Remote Monitoring Middleware (UK).
20. Telstra IoT Health Middleware (Australia).